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رویکرد پیشدارو
Therefore, a growing awareness of finding alternative approaches as determinants of in vivo drug therapeutic activity has led the drug industry to pursue the prodrug approach as a prime priority.
Utilizing the prodrug approach, the potential drug candidate is made available with improved properties.
A har- mony has been reached that the prodrug approach is a promising and well-established strategy to develop new entities with superior efficacy and selectivity and reduced toxicity.
This fact, without doubt, indicates the great success of the prodrug approach.
Traditionally, the prodrug approach was aimed at improving the physicochemical properties of drugs via covalently attaching the drug moiety to a nontoxic chemical species, the promoiety.
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